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The redox-sensitive cation channel TRPM2 modulates phagocyte ROS production and inflammation
The NADPH oxidase activity of phagocytes and its generation of reactive oxygen species (ROS) is critical for host-defense, but ROS overproduction can also lead to inflammation and tissue injury. Here we report that TRPM2, a non-selective and redox-sensitive cation channel, inhibits ROS production in...
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| Main Authors: | , , , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2011
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3242890/ https://ncbi.nlm.nih.gov/pubmed/22101731 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2171 |
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