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Novel Role of ROS-Activated trp Melastatin Channel-2 (TRPM2) in Mediating Angiogenesis and Post-Ischemic Neovascularisation

OBJECTIVE: Transient Receptor Potential Melastatin-2 (TRPM2) channel is a non-selective cation channel that mediates influx of Ca(2+) and Na(+) with relative permeability of PCa:PNa ∼0.6 in response to cellular oxidative stress. As angiogenesis and ischemic neovascularization are both significantly...

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Detalhes bibliográficos
Publicado no:Arterioscler Thromb Vasc Biol
Main Authors: Mittal, Manish, Urao, Norifumi, Hecquet, Claudie M., Zhang, Min, Sudhahar, Varadarajan, Gao, Xiao-pei, Komarova, Yulia, Ushio-Fukai, Masuko, Malik, Asrar B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4396825/
https://ncbi.nlm.nih.gov/pubmed/25675998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.114.304802
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