p53-responsive miR-194 inhibits thrombospondin-1 and promotes angiogenesis in colon cancers

Thrombospondin-1 (TSP-1) is an endogenous inhibitor of angiogenesis encoded by the THBS1 gene, whose promoter is activated by p53. In advanced colorectal cancers (CRC), its expression is sustained or even slightly increased despite frequent loss of p53. Here, we determined that in HCT116 CRC cells,...

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Hauptverfasser: Sundaram, Prema, Hultine, Stacy, Smith, Lauren M., Dews, Michael, Fox, Jamie L., Biyashev, Dauren, Schelter, Janell M., Huang, Qihong, Cleary, Michele A., Volpert, Olga V., Thomas-Tikhonenko, Andrei
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3242824/
https://ncbi.nlm.nih.gov/pubmed/22028325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-11-1124
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