p53-responsive miR-194 inhibits thrombospondin-1 and promotes angiogenesis in colon cancers

Thrombospondin-1 (TSP-1) is an endogenous inhibitor of angiogenesis encoded by the THBS1 gene, whose promoter is activated by p53. In advanced colorectal cancers (CRC), its expression is sustained or even slightly increased despite frequent loss of p53. Here, we determined that in HCT116 CRC cells,...

Descripció completa

Guardat en:
Dades bibliogràfiques
Autors principals: Sundaram, Prema, Hultine, Stacy, Smith, Lauren M., Dews, Michael, Fox, Jamie L., Biyashev, Dauren, Schelter, Janell M., Huang, Qihong, Cleary, Michele A., Volpert, Olga V., Thomas-Tikhonenko, Andrei
Format: Artigo
Idioma:Inglês
Publicat: 2011
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3242824/
https://ncbi.nlm.nih.gov/pubmed/22028325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-11-1124
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars