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Autophagy: An ‘Achilles’ heel of tumorigenesis in TSC and LAM

Mammalian target of rapamycin (mTOR) complex 1 (mTORC1), which is activated in tuberous sclerosis complex (TSC) and lymphangioleiomyomatosis (LAM), is a master regulator of cell growth, cellular metabolism and autophagy. Treatment of TSC and LAM patients with mTORC1 inhibitors partially decreases th...

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Bibliografske podrobnosti
Main Authors: Yu, Jane, Parkhitko, Andrey, Henske, Elizabeth Petri
Format: Artigo
Jezik:Inglês
Izdano: Landes Bioscience 2011
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3242802/
https://ncbi.nlm.nih.gov/pubmed/21997371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/auto.7.11.17652
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