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Autophagy: An ‘Achilles’ heel of tumorigenesis in TSC and LAM
Mammalian target of rapamycin (mTOR) complex 1 (mTORC1), which is activated in tuberous sclerosis complex (TSC) and lymphangioleiomyomatosis (LAM), is a master regulator of cell growth, cellular metabolism and autophagy. Treatment of TSC and LAM patients with mTORC1 inhibitors partially decreases th...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Landes Bioscience
2011
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3242802/ https://ncbi.nlm.nih.gov/pubmed/21997371 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/auto.7.11.17652 |
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