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Mechanism of Ribonuclease A Endocytosis: Analogies to Cell-Penetrating Peptides()

Pancreatic-type ribonucleases can exert toxic activity by catalyzing the degradation of cellular RNA. Their ability to enter cells is essential for their cytotoxicity. Here, we determine the mechanism by which bovine pancreatic ribonuclease (RNase A) enters human cells. Inhibiting clathrin-dependent...

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Autors principals: Chao, Tzu-Yuan, Raines, Ronald T.
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3242730/
https://ncbi.nlm.nih.gov/pubmed/21827164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi2009079
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