Methylenetetrahydrofolate reductase genetic polymorphisms and toxicity to 5-FU-based chemoradiation in rectal cancer

BACKGROUND: There is a large degree of variation in tumour response and host toxicities associated with neoadjuvant chemoradiation for rectal cancer patients. We performed a complimentary pharmacogenetic study to investigate germline polymorphisms of genes involved in 5-fluorouracil (5-FU) and irino...

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Detalhes bibliográficos
Main Authors: Thomas, F, Motsinger-Reif, A A, Hoskins, J M, Dvorak, A, Roy, S, Alyasiri, A, Myerson, R J, Fleshman, J W, Tan, B R, McLeod, H L
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
Assuntos:
Clinical Study
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3242600/
https://ncbi.nlm.nih.gov/pubmed/22045187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2011.442
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