The Methylazoxymethanol Acetate (MAM-E17) Rat Model: Molecular and Functional Effects in the Hippocampus

Administration of the DNA-alkylating agent methylazoxymethanol acetate (MAM) on embryonic day 17 (E17) produces behavioral and anatomical brain abnormalities, which model some aspects of schizophrenia. This has lead to the premise that MAM rats are a neurodevelopmental model for schizophrenia. Howev...

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Détails bibliographiques
Auteurs principaux: Hradetzky, Eva, Sanderson, Thomas M, Tsang, Tsz M, Sherwood, John L, Fitzjohn, Stephen M, Lakics, Viktor, Malik, Nadia, Schoeffmann, Stephanie, O'Neill, Michael J, Cheng, Tammy MK, Harris, Laura W, Rahmoune, Hassan, Guest, Paul C, Sher, Emanuele, Collingridge, Graham L, Holmes, Elaine, Tricklebank, Mark D, Bahn, Sabine
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2012
Sujets:
Original Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3242314/
https://ncbi.nlm.nih.gov/pubmed/21956444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2011.219
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