The Methylazoxymethanol Acetate (MAM-E17) Rat Model: Molecular and Functional Effects in the Hippocampus

Administration of the DNA-alkylating agent methylazoxymethanol acetate (MAM) on embryonic day 17 (E17) produces behavioral and anatomical brain abnormalities, which model some aspects of schizophrenia. This has lead to the premise that MAM rats are a neurodevelopmental model for schizophrenia. Howev...

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Main Authors: Hradetzky, Eva, Sanderson, Thomas M, Tsang, Tsz M, Sherwood, John L, Fitzjohn, Stephen M, Lakics, Viktor, Malik, Nadia, Schoeffmann, Stephanie, O'Neill, Michael J, Cheng, Tammy MK, Harris, Laura W, Rahmoune, Hassan, Guest, Paul C, Sher, Emanuele, Collingridge, Graham L, Holmes, Elaine, Tricklebank, Mark D, Bahn, Sabine
格式: Artigo
語言:Inglês
出版: Nature Publishing Group 2012
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Original Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3242314/
https://ncbi.nlm.nih.gov/pubmed/21956444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2011.219
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