The Methylazoxymethanol Acetate (MAM-E17) Rat Model: Molecular and Functional Effects in the Hippocampus

Administration of the DNA-alkylating agent methylazoxymethanol acetate (MAM) on embryonic day 17 (E17) produces behavioral and anatomical brain abnormalities, which model some aspects of schizophrenia. This has lead to the premise that MAM rats are a neurodevelopmental model for schizophrenia. Howev...

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Detalhes bibliográficos
Main Authors: Hradetzky, Eva, Sanderson, Thomas M, Tsang, Tsz M, Sherwood, John L, Fitzjohn, Stephen M, Lakics, Viktor, Malik, Nadia, Schoeffmann, Stephanie, O'Neill, Michael J, Cheng, Tammy MK, Harris, Laura W, Rahmoune, Hassan, Guest, Paul C, Sher, Emanuele, Collingridge, Graham L, Holmes, Elaine, Tricklebank, Mark D, Bahn, Sabine
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3242314/
https://ncbi.nlm.nih.gov/pubmed/21956444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2011.219
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