Selective Remediation of Reversal Learning Deficits in the Neurodevelopmental MAM Model of Schizophrenia by a Novel mGlu5 Positive Allosteric Modulator

Based on the glutamatergic hypothesis of schizophrenia we assessed the effects of a novel mGlu5 positive allosteric modulator, LSN2463359 [N-(1-methylethyl)-5-(pyridin-4-ylethynyl)pyridine-2-carboxamide] on deficits in cognitive flexibility in two distinct rodent models of schizophrenia, the neurode...

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Autores principales: Gastambide, Francois, Cotel, Marie-Caroline, Gilmour, Gary, O'Neill, Michael J, Robbins, Trevor W, Tricklebank, Mark D
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2012
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3280638/
https://ncbi.nlm.nih.gov/pubmed/22129780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2011.298
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