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The novel Bcl-2 inhibitor ABT-737 is more effective in hypoxia, and is able to reverse hypoxia-induced drug resistance in neuroblastoma cells
Neuroblastoma is a common solid tumour of childhood and advanced disease carries a poor prognosis despite intensive multi-modality therapy. Hypoxia is a common feature of solid tumours due to poorly organised tumour-induced neovasculature. Hypoxia is associated with advanced stage and poor outcome i...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3242074/ https://ncbi.nlm.nih.gov/pubmed/22006676 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-11-0326 |
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