Progressive Induction of Left Ventricular Pressure Overload in a Large Animal Model Elicits Myocardial Remodeling and a Unique Matrix Signature

BACKGROUND: Patients with severe left ventricular (LV) pressure overload (LVPO) secondary to aortic stenosis can present with signs and symptoms of heart failure despite normal LV ejection fractions (LVEF). This process occurs, at least in part, as a result of LVPO-induced extracellular matrix (ECM)...

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Main Authors: Yarbrough, William M., Mukherjee, Rupak, Stroud, Robert E., Rivers, William T., Oelsen, J. Marshall, Dixon, Jennifer A., Eckhouse, Shaina R., Ikonomidis, John S., Zile, Michael R., Spinale, Francis G.
Format: Artigo
Language:Inglês
Published: 2011
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3241904/
https://ncbi.nlm.nih.gov/pubmed/22056365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jtcvs.2011.09.032
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