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G protein-coupled receptor kinases: more than just kinases and not only for GPCRs
G protein-coupled receptor (GPCR) kinases (GRKs) are best known for their role in homologous desensitization of GPCRs. GRKs phosphorylate activated receptors and promote high affinity binding of arrestins, which precludes G protein coupling. GRKs have a multidomain structure, with the kinase domain...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2011
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3241883/ https://ncbi.nlm.nih.gov/pubmed/21903131 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pharmthera.2011.08.001 |
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