Molecular basis of dihydrouridine formation on tRNA

Dihydrouridine (D) is a highly conserved modified base found in tRNAs from all domains of life. Dihydrouridine synthase (Dus) catalyzes the D formation of tRNA through reduction of uracil base with flavin mononucleotide (FMN) as a cofactor. Here, we report the crystal structures of Thermus thermophi...

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Detalhes bibliográficos
Main Authors: Yu, Futao, Tanaka, Yoshikazu, Yamashita, Keitaro, Suzuki, Takeo, Nakamura, Akiyoshi, Hirano, Nagisa, Suzuki, Tsutomu, Yao, Min, Tanaka, Isao
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2011
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3241823/
https://ncbi.nlm.nih.gov/pubmed/22123979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1112352108
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