Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability

Citrate is a critical metabolite required to support both mitochondrial bioenergetics and cytosolic macromolecular synthesis. When cells proliferate under normoxic conditions, glucose provides the acetyl-CoA that condenses with oxaloacetate to support citrate production. Tricarboxylic acid (TCA) cyc...

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Detalhes bibliográficos
Main Authors: Wise, David R., Ward, Patrick S., Shay, Jessica E. S., Cross, Justin R., Gruber, Joshua J., Sachdeva, Uma M., Platt, Jesse M., DeMatteo, Raymond G., Simon, M. Celeste, Thompson, Craig B.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2011
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3241793/
https://ncbi.nlm.nih.gov/pubmed/22106302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1117773108
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