Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability

Citrate is a critical metabolite required to support both mitochondrial bioenergetics and cytosolic macromolecular synthesis. When cells proliferate under normoxic conditions, glucose provides the acetyl-CoA that condenses with oxaloacetate to support citrate production. Tricarboxylic acid (TCA) cyc...

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Bibliographische Detailangaben
Hauptverfasser: Wise, David R., Ward, Patrick S., Shay, Jessica E. S., Cross, Justin R., Gruber, Joshua J., Sachdeva, Uma M., Platt, Jesse M., DeMatteo, Raymond G., Simon, M. Celeste, Thompson, Craig B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2011
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3241793/
https://ncbi.nlm.nih.gov/pubmed/22106302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1117773108
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