Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability

Citrate is a critical metabolite required to support both mitochondrial bioenergetics and cytosolic macromolecular synthesis. When cells proliferate under normoxic conditions, glucose provides the acetyl-CoA that condenses with oxaloacetate to support citrate production. Tricarboxylic acid (TCA) cyc...

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書誌詳細
主要な著者: Wise, David R., Ward, Patrick S., Shay, Jessica E. S., Cross, Justin R., Gruber, Joshua J., Sachdeva, Uma M., Platt, Jesse M., DeMatteo, Raymond G., Simon, M. Celeste, Thompson, Craig B.
フォーマット: Artigo
言語:Inglês
出版事項: National Academy of Sciences 2011
主題:
Biological Sciences
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3241793/
https://ncbi.nlm.nih.gov/pubmed/22106302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1117773108
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