Altered axonal targeting and short-term plasticity in the hippocampus of Disc1 mutant mice

Carefully designed animal models of genetic risk factors are likely to aid our understanding of the pathogenesis of schizophrenia. Here, we study a mouse strain with a truncating lesion in the endogenous Disc1 ortholog designed to model the effects of a schizophrenia-predisposing mutation and offer...

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Detalhes bibliográficos
Main Authors: Kvajo, Mirna, McKellar, Heather, Drew, Liam J., Lepagnol-Bestel, Aude-Marie, Xiao, Lan, Levy, Rebecca J., Blazeski, Richard, Arguello, P. Alexander, Lacefield, Clay O., Mason, Carol A., Simonneau, Michel, O'Donnell, James M., MacDermott, Amy B., Karayiorgou, Maria, Gogos, Joseph A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2011
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PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3241761/
https://ncbi.nlm.nih.gov/pubmed/22049344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1114113108
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