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Role of checkpoint kinase 1 (Chk1) in the mechanisms of resistance to histone deacetylase inhibitors

Histone deacetylase inhibitors (HDACi) are a new group of anticancer drugs with tumor selective toxicity. Normal cells are relatively resistant to HDACi-induced cell death compared with cancer cells. Previously, we found that vorinostat induces DNA breaks in normal and transformed cells, which norma...

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書目詳細資料
Main Authors: Lee, Ju-Hee, Choy, Megan L., Ngo, Lang, Venta-Perez, Gisela, Marks, Paul A.
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2011
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3241758/
https://ncbi.nlm.nih.gov/pubmed/22106282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1117544108
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