Development of a histone deacetylase 6 inhibitor and its biological effects

Development of isoform-selective histone deacetylase (HDAC) inhibitors is important in elucidating the function of individual HDAC enzymes and their potential as therapeutic agents. Among the eleven zinc-dependent HDACs in humans, HDAC6 is structurally and functionally unique. Here, we show that a h...

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Bibliografske podrobnosti
Main Authors: Lee, Ju-Hee, Mahendran, Adaickapillai, Yao, Yuanshan, Ngo, Lang, Venta-Perez, Gisela, Choy, Megan L., Kim, Nathaniel, Ham, Won-Seok, Breslow, Ronald, Marks, Paul A.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2013
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3785767/
https://ncbi.nlm.nih.gov/pubmed/24023063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1313893110
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