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Creation of a histone deacetylase 6 inhibitor and its biological effects

We report the development of a potent, selective histone deacetylase 6 (HDAC6) inhibitor. This HDAC6 inhibitor blocks growth of normal and transformed cells but does not induce death of normal cells. The HDAC6 inhibitor alone is as effective as paclitaxel in anticancer activity in tumor-bearing mice...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Lee, Ju-Hee, Yao, Yuanshan, Mahendran, Adaickapillai, Ngo, Lang, Venta-Perez, Gisela, Choy, Megan L., Breslow, Ronald, Marks, Paul A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4593111/
https://ncbi.nlm.nih.gov/pubmed/26371309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1515882112
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