Creation of a histone deacetylase 6 inhibitor and its biological effects

We report the development of a potent, selective histone deacetylase 6 (HDAC6) inhibitor. This HDAC6 inhibitor blocks growth of normal and transformed cells but does not induce death of normal cells. The HDAC6 inhibitor alone is as effective as paclitaxel in anticancer activity in tumor-bearing mice...

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Detaylı Bibliyografya
Yayımlandı:Proc Natl Acad Sci U S A
Asıl Yazarlar: Lee, Ju-Hee, Yao, Yuanshan, Mahendran, Adaickapillai, Ngo, Lang, Venta-Perez, Gisela, Choy, Megan L., Breslow, Ronald, Marks, Paul A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2015
Konular:
Physical Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4593111/
https://ncbi.nlm.nih.gov/pubmed/26371309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1515882112
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