Drug-Sensitive DNA Polymerase δ Reveals a Role for Mismatch Repair in Checkpoint Activation in Yeast

We have used a novel method to activate the DNA damage S-phase checkpoint response in Saccharomyces cerevisiae to slow lagging-strand DNA replication by exposing cells expressing a drug-sensitive DNA polymerase δ (L612M-DNA pol δ) to the inhibitory drug phosphonoacetic acid (PAA). PAA-treated pol3-L...

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Detalhes bibliográficos
Main Authors: Reha-Krantz, Linda J., Siddique, Md. Shahjahan P., Murphy, Kelly, Tam, Andrea, O’Carroll, Michelle, Lou, Sam, Schultz, Amy, Boone, Charles
Formato: Artigo
Idioma:Inglês
Publicado em: Genetics Society of America 2011
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Investigations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3241404/
https://ncbi.nlm.nih.gov/pubmed/21926300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.111.131938
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