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Sensitivity to Phosphonoacetic Acid: A New Phenotype to Probe DNA Polymerase δ in Saccharomyces cerevisiae

A mutant allele (pol3-L612M) of the DNA polymerase δ gene in Saccharomyces cerevisiae that confers sensitivity to the antiviral drug phosphonoacetic acid (PAA) was constructed. We report that PAA-sensitivity tagging DNA polymerases is a useful method for selectively and reversibly inhibiting one typ...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Li, Lei, Murphy, Kelly M., Kanevets, Uliana, Reha-Krantz, Linda J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Genetics Society of America 2005
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1450396/
https://ncbi.nlm.nih.gov/pubmed/15802517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.104.040295
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