Synthesis and Properties of Molecular Probes for the Rescue Site on Mutant Cystic Fibrosis Transmembrane Conductance Regulator

[Image: see text] Cystic fibrosis is a genetic disease caused by mutations in the gene for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. In vitro experiments have demonstrated that 4-methyl-2-(5-phenyl-1H-pyrazol-3-yl)phenol (VRT-532, 1) is able to partially restore the fun...

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Główni autorzy: Alkhouri, Bashar, Denning, Robert A., Kim Chiaw, Patrick, Eckford, Paul D. W., Yu, Wilson, Li, Canhui, Bogojeski, Jovanka J., Bear, Christine E., Viirre, Russell D.
Format: Artigo
Język:Inglês
Wydane: American Chemical Society 2011
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3241338/
https://ncbi.nlm.nih.gov/pubmed/22074181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm201335c
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