Polycomb Repressed Genes have Permissive Enhancers that Initiate Reprogramming

Key regulatory genes, suppressed by Polycomb and H3K27me3, become active during normal differentiation and induced reprogramming. Using the well-characterized enhancer/promoter pair of MYOD1 as a model, we have identified a critical role for enhancers in reprogramming. We observed an unexpected nucl...

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Hauptverfasser: Taberlay, Phillippa C., Kelly, Theresa K., Liu, Chun-Chi, You, Jueng Soo, de Carvalho, Daniel D., Miranda, Tina B., Zhou, Xianghong J., Liang, Gangning, Jones, Peter A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3240866/
https://ncbi.nlm.nih.gov/pubmed/22153073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2011.10.040
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