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p50 (NF-κB1) is an effector protein in the cytotoxic response to DNA methylation damage
The functional significance of the signaling pathway induced by O(6)-methylguanine (O(6)-MeG) lesions is poorly understood. Here, we identify the p50 subunit of NF-κB as a central target in the response to O(6)-MeG and demonstrate that p50 is required for S(N)1-methylator-induced cytotoxicity. In re...
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| Autori principali: | , , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2011
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3240852/ https://ncbi.nlm.nih.gov/pubmed/22152481 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2011.09.026 |
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