p50 (NF-κB1) is an effector protein in the cytotoxic response to DNA methylation damage

The functional significance of the signaling pathway induced by O(6)-methylguanine (O(6)-MeG) lesions is poorly understood. Here, we identify the p50 subunit of NF-κB as a central target in the response to O(6)-MeG and demonstrate that p50 is required for S(N)1-methylator-induced cytotoxicity. In re...

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Detalhes bibliográficos
Main Authors: Schmitt, Adam M., Crawley, Clayton D., Kang, Shijune, Raleigh, David R., Yu, Xiaohong, Wahlstrom, Joshua S., Voce, David J., Darga, Thomas E., Weichselbaum, Ralph R., Yamini, Bakhtiar
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3240852/
https://ncbi.nlm.nih.gov/pubmed/22152481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2011.09.026
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