Downregulation of the serum response factor/miR-1 axis in the quadriceps of patients with COPD

RATIONALE: Muscle atrophy confers a poor prognosis in patients with chronic obstructive pulmonary disease (COPD), yet the molecular pathways responsible are poorly characterised. Muscle-specific microRNAs and serum response factor (SRF) are important regulators of muscle phenotype that contribute to...

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Autors principals: Lewis, Amy, Riddoch-Contreras, Joanna, Natanek, Samantha A, Donaldson, Anna, Man, William D-C, Moxham, John, Hopkinson, Nicholas S, Polkey, Michael I, Kemp, Paul R
Format: Artigo
Idioma:Inglês
Publicat: BMJ Group 2011
Matèries:
Chronic Obstructive Pulmonary Disease
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3240776/
https://ncbi.nlm.nih.gov/pubmed/21998125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/thoraxjnl-2011-200309
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