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Structural mechanisms of constitutive activation in the C5a receptors with mutations in the extracellular loops: molecular modeling study
Previously we demonstrated by random saturation mutagenesis a set of mutations in the extracellular (EC) loops that constitutively activate the C5a receptor (C5aR) (1,2). In the current study, molecular modeling revealed possible conformations for the extracellular loops of the C5a receptors with mu...
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| Auteurs principaux: | , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2011
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3240690/ https://ncbi.nlm.nih.gov/pubmed/21960464 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.23162 |
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