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DNA methylation and the frequency of CpG in animal DNA.
An analysis of nearest neighbour dinucleotide frequencies and the level of DNA methylation in animals strongly supports the suggestion that 5-methylcytosine (5mC) tends to mutate abnormally frequently to T. This tendency is the likely cause of the CpG deficiency in heavily methylated genomes.
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
1980
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| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC324012/ https://ncbi.nlm.nih.gov/pubmed/6253938 |
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