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Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology.

A monoclonal antibody to the microtubule-associated protein tau (tau) labeled some neurofibrillary tangles and plaque neurites, the two major locations of paired-helical filaments (PHF), in Alzheimer disease brain. The antibody also labeled isolated PHF that had been repeatedly washed with NaDodSO4....

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Grundke-Iqbal, I, Iqbal, K, Tung, Y C, Quinlan, M, Wisniewski, H M, Binder, L I
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1986
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC323854/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3088567/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.83.13.4913
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