Probing the allosteric activation of pyruvate carboxylase using 2′,3′-O-(2,4,6-trinitrophenyl) adenosine 5′-triphosphate as a fluorescent mimic of the allosteric activator acetyl CoA

2′,3′-O-(2,4,6-Trinitrophenyl) adenosine 5′-triphosphate (TNP-ATP) is a fluorescent analogue of ATP. MgTNP-ATP was found to be an allosteric activator of pyruvate carboxylase that exhibits competition with acetyl CoA in activating the enzyme. There is no evidence that MgTNP-ATP binds to the MgATP su...

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Bibliographische Detailangaben
Hauptverfasser: Adina-Zada, Abdussalam, Hazra, Rasmani, Sereeruk, Chutima, Jitrapakdee, Sarawut, Zeczycki, Tonya N., Maurice, Martin St., Cleland, W.Wallace, Wallace, John C., Attwood, Paul V.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3238500/
https://ncbi.nlm.nih.gov/pubmed/21426897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2011.03.006
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