The roles of Arg427 and Arg472 in the binding and allosteric effects of acetyl CoA in pyruvate carboxylase

Mutation of Arg427 and Arg472 in Rhizobium etli pyruvate carboxylase to serine or lysine greatly increased the activation constant (K(a)) of acetyl CoA, with the increase being greater for the Arg472 mutants. These results indicate that while both these residues are involved in the binding of acetyl...

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Main Authors: Adina-Zada, Abdussalam, Sereeruk, Chutima, Jitrapakdee, Sarawut, Zeczycki, Tonya N., St. Maurice, Martin, Cleland, W. Wallace, Wallace, John C., Attwood, Paul V.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3567212/
https://ncbi.nlm.nih.gov/pubmed/22985389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi301060d
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