Greater Impact of Melanocortin-4 Receptor Deficiency on Rates of Growth and Risk of Type 2 Diabetes During Childhood Compared With Adulthood in Pima Indians

Features of melanocortin-4 receptor (MC4R) deficiency have been observed to be more pronounced in childhood. Longitudinal data from a population-based study were used to separate the phenotypic effects of MC4R deficiency during childhood and adulthood. The MC4R exon was sequenced in 6,760 individual...

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Autors principals: Thearle, Marie S., Muller, Yunhua L., Hanson, Robert L., Mullins, Meghan, AbdusSamad, Maryam, Tran, John, Knowler, William C., Bogardus, Clifton, Krakoff, Jonathan, Baier, Leslie J.
Format: Artigo
Idioma:Inglês
Publicat: American Diabetes Association 2012
Matèries:
Genetics/Genomes/Proteomics/Metabolomics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3237672/
https://ncbi.nlm.nih.gov/pubmed/22106157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db11-0708
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