Targeted Loss of GHR Signaling in Mouse Skeletal Muscle Protects Against High-Fat Diet–Induced Metabolic Deterioration

Growth hormone (GH) exerts diverse tissue-specific metabolic effects that are not revealed by global alteration of GH action. To study the direct metabolic effects of GH in the muscle, we specifically inactivated the growth hormone receptor (ghr) gene in postnatal mouse skeletal muscle using the Cre...

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Autores principales: Vijayakumar, Archana, Wu, YingJie, Sun, Hui, Li, Xiaosong, Jeddy, Zuha, Liu, Chengyu, Schwartz, Gary J., Yakar, Shoshana, LeRoith, Derek
Formato: Artigo
Lenguaje:Inglês
Publicado: American Diabetes Association 2012
Materias:
Metabolism
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3237669/
https://ncbi.nlm.nih.gov/pubmed/22187377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db11-0814
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