Synergistic Reversal of Type 1 Diabetes in NOD Mice With Anti-CD3 and Interleukin-1 Blockade: Evidence of Improved Immune Regulation

Inflammatory cytokines are involved in autoimmune diabetes: among the most prominent is interleukin (IL)-1β. We postulated that blockade of IL-1β would modulate the effects of anti-CD3 monoclonal antibody (mAb) in treating diabetes in NOD mice. To test this, we treated hyperglycemic NOD mice with F(...

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Hauptverfasser: Ablamunits, Vitaly, Henegariu, Octavian, Hansen, Jakob Bondo, Opare-Addo, Lynn, Preston-Hurlburt, Paula, Santamaria, Pere, Mandrup-Poulsen, Thomas, Herold, Kevan C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Diabetes Association 2012
Schlagworte:
Immunology and Transplantation
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3237664/
https://ncbi.nlm.nih.gov/pubmed/22043003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db11-1033
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