The tandem chain extension aldol reaction used for synthesis of ketomethylene tripeptidomimetics targeting hPEPT1

The rationale for targeting the human di-/tripeptide transporter hPEPT1 for oral drug delivery has been well established by several drug and prodrug cases. The aim of this study was to synthesize novel ketomethylene modified tripeptidomimetics and to investigate their binding affinity for hPEPT1. Th...

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Bibliographic Details
Main Authors: Thorn, Karina, Nielsen, Carsten Uhd, Jakobsen, Palle, Steffansen, Bente, Zercher, Charles K., Begtrup, Mikael
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3237634/
https://ncbi.nlm.nih.gov/pubmed/21703856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2011.05.108
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