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Analysis of the phorbol ester pharmacophore on protein kinase C as a guide to the rational design of new classes of analogs.

The diterpene diester phorbol 12-myristate 13-acetate and the alkaloid teleocidin B are structurally unrelated natural products that display similar potent irritant and tumor-promoting activities. Computer modeling of these and other structural classes of tumor promoters show a marked similarity in...

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Bibliografiske detaljer
Main Authors: Wender, P A, Koehler, K F, Sharkey, N A, Dell'Aquila, M L, Blumberg, P M
Format: Artigo
Sprog:Inglês
Udgivet: 1986
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC323702/
https://ncbi.nlm.nih.gov/pubmed/3086877
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