Analysis of the phorbol ester pharmacophore on protein kinase C as a guide to the rational design of new classes of analogs.

The diterpene diester phorbol 12-myristate 13-acetate and the alkaloid teleocidin B are structurally unrelated natural products that display similar potent irritant and tumor-promoting activities. Computer modeling of these and other structural classes of tumor promoters show a marked similarity in...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Wender, P A, Koehler, K F, Sharkey, N A, Dell'Aquila, M L, Blumberg, P M
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1986
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC323702/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3086877/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.83.12.4214
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