MYCN and MYC regulate tumor proliferation and tumorigenesis directly through BMI1 in human neuroblastomas

The BMI1 gene is overexpressed in ∼90% of human neuroblastomas. However, little is known about the regulation of BMI1 expression. Using microarray and immunohistochemical analysis, we show that BMI1 expression correlated with MYCN levels in MYCN-amplified human neuroblastomas, and with MYC levels in...

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Detalhes bibliográficos
Main Authors: Huang, Ruimin, Cheung, Nai-Kong V., Vider, Jelena, Cheung, Irene Y., Gerald, William L., Tickoo, Satish K., Holland, Eric C., Blasberg, Ronald G.
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2011
Assuntos:
Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3236625/
https://ncbi.nlm.nih.gov/pubmed/21856782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.11-185033
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