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The Importance of Being Profiled: Improving Drug Candidate Safety and Efficacy Using Ion Channel Profiling
Profiling of putative lead compounds against a representative panel of relevant enzymes, receptors, ion channels, and transporters is a pragmatic approach to establish a preliminary view of potential issues that might later hamper development. An early idea of which off-target activities must be min...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Frontiers Research Foundation
2011
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3236397/ https://ncbi.nlm.nih.gov/pubmed/22171219 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2011.00078 |
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