The Importance of Being Profiled: Improving Drug Candidate Safety and Efficacy Using Ion Channel Profiling

Profiling of putative lead compounds against a representative panel of relevant enzymes, receptors, ion channels, and transporters is a pragmatic approach to establish a preliminary view of potential issues that might later hamper development. An early idea of which off-target activities must be min...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Kaczorowski, Gregory J., Garcia, Maria L., Bode, Jacob, Hess, Stephen D., Patel, Umesh A.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Frontiers Research Foundation 2011
Gaiak:
Pharmacology
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3236397/
https://ncbi.nlm.nih.gov/pubmed/22171219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2011.00078
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