Peroxisome Proliferator-Activated Receptor-α Activation Decreases Mean Arterial Pressure, Plasma Interleukin-6, and COX-2 While Increasing Renal CYP4A Expression in an Acute Model of DOCA-Salt Hypertension

Peroxisome proliferator-activated receptor-alpha (PPAR-α) activation by fenofibrate reduces blood pressure and sodium retention during DOCA-salt hypertension. PPAR-α activation reduces the expression of inflammatory cytokines, such as interleukin-6 (IL-6). Fenofibrate also induces cytochrome P450 4A...

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Detalhes bibliográficos
Main Authors: Lee, Dexter L., Wilson, Justin L., Duan, Rong, Hudson, Tamaro, El-Marakby, Ahmed
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3236317/
https://ncbi.nlm.nih.gov/pubmed/22190908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2011/502631
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