Development of Allele-Specific Therapeutic siRNA in Meesmann Epithelial Corneal Dystrophy

BACKGROUND: Meesmann epithelial corneal dystrophy (MECD) is an inherited eye disorder caused by dominant-negative mutations in either keratins K3 or K12, leading to mechanical fragility of the anterior corneal epithelium, the outermost covering of the eye. Typically, patients suffer from lifelong ir...

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Autors principals: Liao, Haihui, Irvine, Alan D., MacEwen, Caroline J., Weed, Kathryn H., Porter, Louise, Corden, Laura D., Gibson, A. Bethany, Moore, Jonathan E., Smith, Frances J. D., McLean, W. H. Irwin, Moore, C. B. Tara
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2011
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3236202/
https://ncbi.nlm.nih.gov/pubmed/22174841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0028582
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