Allele-specific siRNA silencing for the common Keratin 12 founder mutation in Meesmann epithelial corneal dystrophy

PURPOSE: To identify an allele-specific siRNA, against the common KRT12 mutation Arg135Thr in Meesmann epithelial corneal dystrophy (MECD) as a personalized approach to treatment. METHODS: siRNAs against the K12 Arg135Thr mutation were evaluated using a dual luciferase reporter gene assay and the mo...

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Main Authors: Allen, Edwin H. A., Atkinson, Sarah D., Liao, Haihui, Moore, Jonathan E., Pedrioli, Deena M. Leslie, Smith, Frances J. D., McLean, W. H. Irwin, Moore, C. B. Tara
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3869971/
https://ncbi.nlm.nih.gov/pubmed/23233254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.12-10528
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