Clinical significance of SF3B1 mutations in myelodysplastic syndromes and myelodysplastic/myeloproliferative neoplasms

In a previous study, we identified somatic mutations of SF3B1, a gene encoding a core component of RNA splicing machinery, in patients with myelodysplastic syndrome (MDS). Here, we define the clinical significance of these mutations in MDS and myelodysplastic/myeloproliferative neoplasms (MDS/MPN)....

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Detalhes bibliográficos
Main Authors: Malcovati, Luca, Papaemmanuil, Elli, Bowen, David T., Boultwood, Jacqueline, Della Porta, Matteo G., Pascutto, Cristiana, Travaglino, Erica, Groves, Michael J., Godfrey, Anna L., Ambaglio, Ilaria, Gallì, Anna, Da Vià, Matteo C., Conte, Simona, Tauro, Sudhir, Keenan, Norene, Hyslop, Ann, Hinton, Jonathan, Mudie, Laura J., Wainscoat, James S., Futreal, P. Andrew, Stratton, Michael R., Campbell, Peter J., Hellström-Lindberg, Eva, Cazzola, Mario
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2011
Assuntos:
Plenary Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3236114/
https://ncbi.nlm.nih.gov/pubmed/21998214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-09-377275
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