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Adenosine A2a receptor antagonists attenuate striatal adaptations following dopamine depletion

The motor symptoms of Parkinson’s disease (PD) are widely thought to arise from an imbalance in the activity of the two major striatal efferent pathways following the loss of dopamine (DA) signaling. In striatopallidal, indirect pathway spiny projection neurons (iSPNs), intrinsic excitability rises...

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Bibliografiske detaljer
Main Authors: Peterson, Jayms D., Goldberg, Joshua A., Surmeier, D. James
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3235740/
https://ncbi.nlm.nih.gov/pubmed/21964253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2011.08.030
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