Lentiviral vectors express chondroitinase ABC in cortical projections and promote sprouting of injured corticospinal axons

Several diseases and injuries of the central nervous system could potentially be treated by delivery of an enzyme, which might most effectively be achieved by gene therapy. In particular, the bacterial enzyme chondroitinase ABC is beneficial in animal models of spinal cord injury. We have adapted th...

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Autores principales: Zhao, Rong-Rong, Muir, Elizabeth M., Alves, João Nuno, Rickman, Hannah, Allan, Anna Y., Kwok, Jessica C., Roet, Kasper C.D., Verhaagen, Joost, Schneider, Bernard L., Bensadoun, Jean-Charles, Ahmed, Sherif G., Yáñez-Muñoz, Rafael J., Keynes, Roger J., Fawcett, James W., Rogers, John H.
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier/North-Holland Biomedical Press 2011
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3235548/
https://ncbi.nlm.nih.gov/pubmed/21855577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jneumeth.2011.08.003
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