Deletion of Densin-180 Results in Abnormal Behaviors Associated with Mental Illness and Reduces mGluR5 and DISC1 in the Postsynaptic Density Fraction

Densin is an abundant scaffold protein in the postsynaptic density (PSD) that forms a high-affinity complex with αCaMKII and α-actinin. To assess the function of densin, we created a mouse line with a null mutation in the gene encoding it (LRRC7). Homozygous knock-out mice display a wide variety of...

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Main Authors: Carlisle, Holly J., Luong, Tinh N., Medina-Marino, Andrew, Schenker, Leslie, Khorosheva, Eugenia, Indersmitten, Tim, Gunapala, Keith M., Steele, Andrew D., O'Dell, Thomas J., Patterson, Paul H., Kennedy, Mary B.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2011
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3235477/
https://ncbi.nlm.nih.gov/pubmed/22072671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5877-10.2011
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